Prevention remains the paramount challenge of the HIV epidemic, and the major priority for the next five years of PEPFAR. Successful prevention programs require a combination of evidence-based, mutually reinforcing biomedical, behavioral, and structural interventions. PEPFAR is expanding its prevention activities with an emphasis on the following:

  • Working with countries to track and reassess the epidemiology of the epidemic, in order to fashion a prevention response based on best available and most recent data;
  • Emphasizing prevention strategies that have been proven effective and targeting interventions to most at-risk populations with high incidence rates; and
  • Increasing emphasis on supporting and evaluating innovative and promising prevention methods.

Targets from Fiscal Year (FY) 2010- FY 2014:

  • Support the prevention of more than 12 million new HIV infections;
  • Ensure that every partner country with a generalized epidemic has both 80% coverage of testing for pregnant women at the national level, and 85% coverage of antiretroviral drug (ARV) prophylaxis and treatment, as indicated, of women found to be HIV-infected;
  • Double the number of at-risk babies born HIV-free, from the 240,000 babies of HIV-positive mothers who were born HIV-negative during the first five years of PEPFAR;
  • In every partner country with a generalized epidemic, provide 100% of youth in PEPFAR prevention programs with comprehensive and correct knowledge of the ways HIV/AIDS is transmitted and ways to protect themselves, consistent with Millennium Development Goal indicators in this area.

Progress Achieved through September 30, 2009:

  • In FY 2009, PEPFAR directly supported prevention of mother-to-child transmission programs that allowed nearly 100,000 babies of HIV-positive mothers to be born HIV-free, adding to the nearly 240,000 babies born without HIV due to PEPFAR support during FYs 2004-2008.
  • In FY 2009, PEPFAR also directly supported HIV counseling and testing for nearly 29 million people, providing a critical entry point to prevention, treatment, and care.
  • Tables with results achieved by PEPFAR prevention programs during Fiscal Year (FY) 2009 may be found here.

For more information on PEPFAR's data collection, please visit:

Programmatic Strategy: In this second phase of PEPFAR, a new program strategy is underway that supports the Administration's overall emphasis on improving health outcomes, increasing program sustainability and integration, and strengthening health systems. Some of these changes are already being implemented with planning and programming for FY 2010. Over the next year, PEPFAR will be working closely with country teams in order to translate, prioritize, and implement this strategy in a manner appropriate to the country context. More information on the broader strategic framework for PEPFAR activities can be found in the strategy annexes which will be made available at

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