| AB | Abstinence, Be faithful | |
| ABC | Abstinence, Be faithful, and, as appropriate, correct and consistent use of Condoms | |
| ACT | Artemisin-based combination therapy (for malaria) | |
| AEI | African Education Initiative | |
| AIS | AIDS Indicator Surveys | |
| ANC | Antenatal clinic | |
| ART | Antiretroviral treatment | |
| ARV | Antiretroviral drug | |
| BMIST | Battlefield Medical Information System-Tactical | |
| CBO | Community-based organization | |
| CCM | Country Coordinating Mechanism | |
| CDC | Centers for Disease Control and Prevention (U.S.) | |
| COP | Country Operational Plan | |
| COPRS | Country Operational Plan and Reporting System | |
| COM | Chief of Mission | |
| CPT | Co-trimoxazole preventive therapy | |
| CY | Calendar year | |
| DBS | Dried blood spot | |
| DHAPP | Department of Defense HIV/AIDS Prevention Program | |
| DHS | Demographic and Health Survey | |
| DoC | Department of Commerce (U.S.) | |
| DoD | Department of Defense (U.S.) | |
| DoL | Department of Labor (U.S.) | |
| DOTS | Directly Observed Therapy, Short Course | |
| DRA | Drug regulatory authority | |
| DTC | Diagnostic testing and counseling | |
| FBO | Faith-based organization | |
| FDA | Food and Drug Administration | |
| FDC | Fixed-dose combination (formulation) | |
| FY | Fiscal year | |
| GAP | Global AIDS Program (Centers for Disease Control and Prevention) | |
| GBV | Gender-based violence | |
| GIS | Geographic Information Systems | |
| GTT | Global Task Team on Improving AIDS Coordination Among Multilateral Institutions and International Donors | |
| HAART | Highly Active Antiretroviral Therapy | |
| HBC | Home-based care | |
| HHS | Department of Health and Human Services (U.S.) | |
| HMIS | Health management information systems | |
| HRH | Human resources for health | |
| HRSA | Health Resource and Services Administration | |
| ICT | Information and communications technology | |
| IDU | Injecting drug user | |
| IT | Information technology | |
| MAP | Multi-Country AIDS Programme (World Bank) | |
| M&E | Monitoring and evaluation | |
| MoH | Ministry of Health | |
| MSM | Men who have sex with men | |
| NACP | National AIDS Control Program | |
| NGO | Non-governmental organization | |
| NIAID | National Institute of Allergy and Infectious Diseases | |
| NIH | National Institutes of Health | |
| NPI | New Partners Initiative | |
| NRL | National Resource Laboratory | |
| OGAC | Office of the U.S. Global AIDS Coordinator | |
| OI | Opportunistic infection | |
| OMB | Office of Management and Budget | |
| OVC | Orphans and vulnerable children | |
| PART | Performance Assessment Rating Tool | |
| PCR | Polymerase chain reaction | |
| PDA | Personal digital assistant | |
| PEP | Post-exposure prophylaxis | |
| PEPFAR | President�s Emergency Plan for AIDS Relief (Emergency Plan) | |
| PHE | Public Health Evaluation | |
| PLWHA | People living with HIV/AIDS | |
| PMI | Presidential Malaria Initiative | |
| PMTCT | Prevention of mother-to-child HIV transmission | |
| PPP | Public-private partnership | |
| PR | Principal recipient | |
| PSC | Policy and Strategy Committee | |
| SAMHSA | Substance Abuse and Mental Health Services Administration | |
| SCMS | Supply Chain Management System | |
| SI | Strategic information | |
| STI | Sexually transmitted infection | |
| TB | Tuberculosis | |
| UNAIDS | Joint United Nations Programme on HIV/AIDS | |
| UNHCR | United Nations High Commission for Refugees | |
| UNICEF | United Nations Children�s Fund | |
| USAID | United States Agency for International Development | |
| USAID/OIG | U.S. Agency for International Development Office of the Inspector General | |
| USG | United States Government | |
| VCT | Voluntary counseling and testing | |
| WHO | World Health Organization | |
| XDR-TB | Extensively Drug-Resistant Tuberculosis | |
| ZDV | Zidovudine |
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