PEPFAR Prevention Guidance


   

1. Table of Contents

1. INTRODUCTION

1.1 Purpose

1.2 The global HIV prevention context

1.3 PEPFAR’s strategy: combination prevention

2. KNOW YOUR EPIDEMIC, CONTEXT, RESPONSE, AND COSTS

2.1 The Four "Knows"

2.2 Using computer modeling to estimate population-level effects of HIV prevention activities

3. HIV PREVENTION AS PART OF THE COUNTRY CONTINUUM OF RESPONSE

3.1 Supporting the country continuum of response

3.2 Overarching principles of PEPFAR prevention programming

4. EVIDENCE AND IMPLEMENTATION GUIDANCE ON SPECIFIC INTERVENTIONS

4.1 Levels of evidence for elements of combination prevention

4.2 Biomedical interventions for prevention of sexual transmission

4.2.1 Male and female condoms

4.2.2 Voluntary medical male circumcision (VMMC)

4.2.3 HIV testing and counseling (HTC)

4.2.4 Diagnosis and treatment of sexually transmitted infections (STIs)

4.2.5 Antiretroviral drug (ARV)-based prevention

4.3 Behavioral interventions for prevention of sexual transmission

4.3.1 Standalone behavioral interventions to minimize sexual risk or increase protection

4.3.2 Supportive behavioral interventions to optimize biomedical prevention

4.4 Structural supports for sexual prevention

4.4.1 Legal and policy reform

4.5 Prevention packages for specific populations

4.5.1 Comprehensive package for most-at-risk populations (MARPs)

4.5.2 Positive Health, Dignity and Prevention (PHDP): Prevention for people living with HIV

4.5.3 Prevention interventions for young people

5. ASSEMBLING A PORTFOLIO OF INTERVENTIONS

5.1 Categories of activities

5.2 Prioritizing and assembling the portfolio: defining the continuum of response by population and geography

Table 1: Examples of how to apply prevention priorities across different epidemic-types.Appendix: HIV prevention and the Global Health Initiative (GHI): connecting to the broader country continuum of response

Appendix: HIV prevention and the Global Health Initiative (GHI): connecting to the broader country continuum of response

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